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New Study Finds Long Term COVID-19 Risk Linked To Hypertension And Women

Long-term COVID-19 or coronavirus risk is linked to female gender, hypertension, and the frequency of first symptoms.

New Study Finds Long Term COVID-19 Risk Linked To Hypertension And Women
Image: Coronavirus or COVID-19 | InStyleHealth

Women, hypertensives, and individuals with a higher number of early symptoms had a higher likelihood of having protracted COVID-19 (coronavirus), according to a study, and these relationships are independent of illness severity and clinical course.

The study comprised 316 COVID-19 patients (mean age 64 years, 59% male) who were discharged and observed for four months. The median number of symptoms at the time of admission was five. Hyperthermia (79.1%), cough (70.6%), dyspnea (68%) and myalgia (68%) were the most prevalent (50.6 percent).

201 patients (63.6 percent) reported at least one persisting symptom following a median follow-up of 115 days after hospital release. Dyspnea (39.2%) and asthenia were the most common chronic symptoms (37.1 percent).

Patients who had a protracted COVID-19 had a higher prevalence of hypertension than those who had a symptom-free follow-up. During hospitalization, there was no difference in the need for oxygen therapy, admission to the critical care unit, inflammatory markers, or CT-scan abnormalities between the two groups.

In a multivariate logistic regression model, female sex (odds ratio [OR], 1.94, 95 percent confidence interval [CI], 1.17–3.22; p=0.01), hypertension (OR, 2.01, 95 percent CI, 1.22–3.31; p0.01), and a higher number of initial symptoms (OR, 1.35, 95 percent CI, 1.17–1.54; p0.001) were all associated with persistent symptoms.

Further analysis revealed that the number of persistent symptoms was related to the number of initial symptoms (aIRR, 1.16, 95 percent CI, 1.11–1.22; p0.001), as well as female sex (aIRR, 1.56, 95 percent CI, 1.29–1.87; p0.001), hypertension (aIRR, 1.23, 95 percent CI, 1.02–1.50; p=0.03), and hospital stay length (aIRR, 1.01, 95 percent CI, 1.005–1.017; p<0.001). 

The information presented here could be utilized to prioritize early intervention and rehabilitation efforts.

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