Metastatic Cutaneous Squamous Cell Carcinoma High Survival Rate, Study Finds

 

In cutaneous squamous cell carcinoma, metastasis is uncommon, however survival is high.

Metastatic Cutaneous Squamous Cell Carcinoma High Survival Rate, Study Finds
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According to a recent Dutch study, metastasis is uncommon among patients with cutaneous squamous cell carcinoma (cSCC), albeit it may be more likely in men, older patients, and those who are immunocompromised. Metastatic cSSC (mCSSC) has a high disease-specific survival rate.


Researchers used data from the Netherlands Cancer Registry to conduct a statewide investigation, obtaining information on 11,137 patients diagnosed with their first cSSC in 2007 or 2008. A total of 217 patients with mcSSC were verified after a median follow-up of 9.1 years. The majority of metastases occurred within the first four years of a patient's diagnosis.

 

Over the course of ten years of follow-up, the overall cumulative incidence rate of mcSSC was barely 1.9 percent, with an estimated time to occurrence of 1.5 years. The incidence rate of mcSSC was substantially higher in men than in women (2.3 percent vs. 1.4 percent; p0.001).

 

Men were marginally but significantly more likely than women to develop mcSSC (hazard ratio [HR], 1.7, 95 percent confidence range [CI], 1.3–2.3), as did older patients, with each year of increased age raising the risk by 3% (HR, 1.03, 95 percent confidence interval [CI], 1.02–1.05).

 

Immunocompromised people, notably those with hematologic malignancies (HR, 2.7, 95 percent CI, 1.6–4.6) and organ transplant patients (HR, 5.0, 95 percent CI, 2.5–10.0), had a significantly higher risk of mcSSC.

 

In terms of survival, researchers reported a disease-specific 5-year survival rate of 99.4%. Overall survival was substantially lower, at 69.8%, because the majority of deaths were due to other causes.

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