According to a recent study, women appear to be at increased risk of colorectal cancer death following adenoma excision, whilst males appear to be at lower risk.
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| Image: Cancer Cells Attacking Colon | InStyleHealth |
The study comprised 40,293 people who had adenomas
removed in Norway, with 19,725 women (49.0%) and 20,568 males participating
(51.0 percent). With 26,461 survivors followed for 10 years or more, the total
follow-up time was 492,736 person-years (median 13.0 years).
During the study's follow-up period, 1,079 women
(5.5%) and 866 men (4.2%) had colorectal cancer. Colorectal cancer claimed the
lives of 328 women and 275 men.
For women, the median age at first adenoma was 67.0
years, colorectal cancer diagnosis was 79.9 years, and colorectal cancer death
was 80.2 years; for men, the median age at first adenoma was 65.4 years,
colorectal cancer diagnosis was 79.9 years, and colorectal cancer death was
80.2 years.
Colorectal cancer incidence was significantly higher
in women (SIR 1.64, 95 percent confidence interval [CI] 1.54–1.74) than in men
(SIR 1.12, 95 percent confidence interval [CI] 1.05–1.19). Furthermore, women
had a higher risk of colorectal cancer (standardized incidence-based mortality
ratio [SMR], 1.13, 95 percent confidence interval [CI], 1.02–1.26). Men, on the
other hand, had a reduced mortality rate from colorectal cancer (SMR, 0.79, 95
percent CI, 0.71–0.89).
Women with high-risk adenomas (two adenomas, villous
component, or high-grade dysplasia; SMR, 1.37, 95 percent CI, 1.19–1.57) had
the highest risk of colorectal cancer death. Men with high-risk adenomas had a
similar risk (SMR, 0.89, 95 percent CI, 0.76–1.04), but men with low-risk
adenomas had the lowest risk of colorectal cancer death (SMR, 0.70, 95 percent
CI, 0.59–0.84).
The findings emphasize the significance of
sex-specific post-adenoma surveillance recommendations.