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Low Salt Diet Lowers Negative Renal Outcomes in Chronic Kidney Disease

In chronic kidney illness, a low-salt diet lowers the likelihood of negative renal outcomes.

Low Salt Diet Lowers Negative Renal Outcomes in Chronic Kidney Disease
Image: Low Salt Diet Healthy Food | InStyleHealth


Patients with chronic kidney disease (CKD) may benefit from a low-salt diet, according to a study that found the diet helps reduce the occurrence of renal composite end events.

Researchers conducted a systematic review and meta-analysis of studies that looked at the effects of a low-salt diet on renal composite outcomes (more than 50% decline in estimated glomerular filtration rate [eGFR] during follow-up, doubling of serum creatinine, or end-stage renal disease), rate of eGFR decline, proteinuria change, all-cause mortality events, cardiovascular (CV) events, and changes in systolic and diastolic blood pressure.

The meta-analysis comprised 33 research (13 randomized controlled trials and 19 cohort studies) with a total of 101,077 participants (average age 56 years, 60% male). The individuals' average eGFR was 47.45 mL/min/1.73 m2, and the median follow-up was 6 months. Twelve research investigated different levels of sodium intake, while 21 studies compared usual care or usual diet control.

A low-salt diet reduced renal composite outcome events by 28% (relative risk [RR], 0.72, 95 percent confidence interval [CI], 0.58–0.89), according to pooled data.

Other outcomes, such as proteinuria (SMD, 0.71, 95 percent CI, 1.66 to 0.24), rate of eGFR (decline mean difference, 1.16, 95 percent CI, 2.02 to 4.33), all-cause mortality (RR, 0.92, 95 percent CI, 0.58–1.46), and CV events (RR, 1.01, 95 percent CI, 0.46–2.22), were not significantly improved by the diet.

To determine the appropriate dietary salt consumption for individuals with various stages of CKD, more trials with patients with various stages of CKD are required.

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