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How Low-Calorie Ketogenic Diet and Omega 3 Help Weight Loss in Obesity

How a low-calorie ketogenic diet and omega 3 can help lose weight in obesity. A very low-calorie ketogenic diet (VLCKD) combined with omega-3 supplementation leads in fat mass loss while fat-free mass (FFM) is preserved in people with class I obesity, according to a study. Additionally, satiety hormones, such as ghrelin and leptin, as well as metabolic profiles, have improved.


How Low-Calorie Ketogenic Diet and Omega 3 Help Weight Loss in Obesity
Image: Ketogenic Diet | InStyleHealth

Twelve women and three men with BMIs of 30–35 kg/m2 and a history of failed dieting attempts participated in the pilot trial. The population had a median age of 56.5 years and a BMI of 33.84 kg/m2.


The intervention was divided into three stages: active weight loss, dietary re-education, and maintenance, and it lasted three months. A very low-calorie (600–800 kcal/day), low-carbohydrate (20–50 g/day from vegetables), and low-fat (10 g/day olive oil) diet was followed during the active stage.


The active stage was divided into three steps: step 1, the patients ate high-biological-value protein preparations five times a day, along with low-glycemic-index vegetables; step 2, one of the protein servings was replaced with a natural protein food (e.g., meat or fish), either at lunch or dinner; and step 3, a second protein preparation was replaced with a natural protein food.


Throughout the ketogenic stage of the diet, international standards for vitamins, minerals (including potassium, salt, magnesium, and calcium), and omega-3 fatty acids were followed.


Body weight and waist circumference both reduced by 13.7 kg and 13.3 cm during the course of three months. Fat mass and visceral adipose tissue both decreased by 9.1 and 0.41 kg, respectively. FFM did not alter significantly.


Improvements were also seen in the satiety hormones, with ghrelin rising and leptin falling, as well as metabolic profiles.

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