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Depression Increases Risk of Coronary Artery Disease In Diabetic Patients Study Finds

According to the findings of a Mendelian randomization research, there appears to be genetic evidence that depression increases the risk of coronary artery disease (CAD) in diabetic patients.

Depression Increases Risk of Coronary Artery Disease In Diabetic Patients Study Finds
Image: Depressed Senior with Diabetes | InStyleHealth

Researchers looked at single-nucleotide polymorphisms (SNPs) linked to depression (807,553 people), anxiety (83,556 people), and neuroticism (83,556 people) using data from the greatest genome-wide association studies (GWAS) (329,821 individuals). From a recently published GWAS of 15,666 diabetic individuals, they collected summary-level data for CAD (3,968 CAD cases and 11,696 controls).


The inverse-variance weighted (IVW) technique revealed a significant link between genetic susceptibility to depression and a greater incidence of CAD in diabetic individuals (odds ratio, 1.286, 95 percent confidence range, 1.018–1.621; p=0.035).


Anxiety and neuroticism, on the other hand, were not linked to coronary artery disease.


The weighted median, maximum likelihood, and MR-Egger methods all yielded consistent results in sensitivity studies.


The causal effect of depression on CAD could be explained by a number of ways. The secretion of corticotropin-releasing hormone is increased in persons with depression. As a result, glucocorticoids are overproduced, glucocorticoid receptor sensitivity is decreased, and the negative feedback system of the hypothalamic-pituitary-adrenal axis is disrupted. Evidence also suggests that depression might decrease blood sugar management and lead to insulin resistance when accompanied by behavioral changes (e.g., irregular diet and medication nonadherence). [Diabetes Care 2008;31:2398-2403]


In order to avoid CAD, the findings emphasize the significance of providing mental health treatments to diabetic patients.

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