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Hypertension Is Associated with Heart Damage Among COVID-19 Patients, Study Finds

According to a new study, hypertension increases the likelihood of heart damage and a severe disease phenotype in patients with the coronavirus disease 2019 (COVID-19).

Hypertension Is Associated with Heart Damage Among COVID-19 Patients, Study Finds
Image: Patient Blood Pressure Monitoring | InStyleHealth

There were 388 COVID-19 patients in the trial (mean age 47.5 +15.2, 50.8 percent men), 75 of them had hypertension and the other 313 were designated as normotensive controls. Biomarkers such as creatine kinase (CK), CK-myocardial band (CK-MB), myoglobin, and lactate dehydrogenase were used to assess cardiac damage (LDH).

Patients with hypertension had significantly greater levels of markers than normotensive controls. Furthermore, correlation analysis demonstrated a statistically significant relationship between systolic blood pressure and CK (R, 0.124; p=0.01) and LDH (R, 0.103; p=0.05). Myoglobin (R, 0.113; p=0.06) and LDH (R, 0.089; p=0.09), on the other hand, were marginally linked with diastolic blood pressure (R, 0.113; p=0.06).

Hypertension was also linked with cardiac damage markers such as CK-MB (odds ratio [OR], 2.50, 95 percent confidence interval [CI], 0.98–6.39; p=0.05) and LDH (OR, 2.64, 95 percent confidence interval [CI], 1.53–4.57; p=0.001). Such interactions with CK and myoglobin were not found to be statistically significant (p=0.59 and p=0.14, respectively).

"To our knowledge, this is the first publication to provide comprehensive information on epidemiological, demographic, clinical, laboratory, and radiological aspects of hospitalized COVID-19 patients in the setting of hypertension and resulting cardiac injury," the researchers wrote.

"Our findings revealed a substantial link between hypertension and cardiac damage in COVID-19 patients," they noted, implying that better blood pressure control could help improve COVID-19 results.


Source: Sci Rep 2021;11:22389

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