Antihistamine Increases Appetite In Adults Study Finds

According to a study, cyproheptadine causes hunger in adults who have a low appetite.

Antihistamine Increases Appetite In Adults Study Finds
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A total of 375 patients with a weak appetite, ranging in age from 19 to 64, were randomized to receive either cyproheptadine (n=189) or placebo (n=186) for an 8-week period. From the beginning until the completion of the trial period, the primary efficacy outcome of a change in appetite was monitored using the Korean version of the Edmonton Symptom Assessment System.

Weight, anthropometrics, body composition, Simplified Nutritional Hunger Questionnaire–measured appetite, and toxicities were also studied.

At week 8, the cyproheptadine group had a higher mean change in appetite score (–2.42 vs –2.03, respectively), indicating a statistically significant appetite gain with the study treatment (difference, 0.38, 95 percent confidence interval, –0.73 to –0.04; p=0.0307).

As a result, cyproheptadine-treated individuals gained significant weight and had a higher BMI.

Cyproheptadine was well tolerated in terms of safety. As expected, somnolence was the most common adverse event. One patient in the active therapy group developed colitis, which was classed as a moderate side event that was unlikely to be caused by cyproheptadine.

Cyproheptadine is an antihistamine and antiserotonergic medication used to increase hunger and encourage weight gain in both children and adults. The findings show that cyproheptadine is a safe therapeutic choice for people with a lack of appetite.

More research is needed to determine the efficacy of cyproheptadine in elderly people.

Source: Clin Ther 2021;43:1757-1772

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