According to a study, the majority of individuals with chronic pancreatitis also have osteoporosis or osteopenia, with risk factors including older age and a lower body mass index (BMI).
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In the PROCEED trial, 282 people with definite chronic
pancreatitis were included in the analysis. A baseline dual-energy X-ray
absorptiometry (DXA) scan had been performed on all of them.
The lowest T-scores were used to define osteopenia and
osteoporosis, and clinical data was obtained using standardized case report
forms. They used a multivariate logistic regression model with forward
selection to compare risk factors for osteopathy.
On DXA screening, more than half of the patients
(56.0%) had osteopathy, with 17.0 percent having osteoporosis and 39.0 percent
having osteopenia. Participants with bone disorders showed a greater rate of
traumatic fractures (40.0 percent vs 26.4 percent; p=0.02) and spontaneous
fractures (3.9 percent vs 0 percent; p=0.04) than non-osteopathy controls.
Older age (per 5 years: odds ratio [OR], 1.29, 95
percent confidence interval [CI], 1.15–1.45), female sex (OR, 3.08, 95 percent
CI, 1.75–5.43), White race (OR, 2.68, 95 percent CI, 1.20–6.01), and
underweight BMI category (OR, 7.40, 95 percent CI, 1.56–34.99) were all
associated with a higher risk of osteopathy in multivariate logistic regression
analysis.
There were no significant relationships between
osteopathy and patient and disease-related characteristics of chronic pancreatitis. More research is needed to figure out what causes bone loss in
chronic pancreatitis.
Source: Clin Gastroenterol Hepatol
2021;doi:10.1016/j.cgh.2021.09.026