Patients with Congenital Heart Disease Suffer From High Rates of Early Vascular Ageing

A recent study has discovered that patients with congenital heart disease suffer from high rates of early vascular ageing or EVA. Blood pressure, pulse pressure, and blood sugar are among the risk factors for early vascular ageing.

Patients with Congenital Heart Disease Suffer From High Rates of  Early Vascular Ageing
Photo: A Human Heart | InStyleHealth


What Is Congenital Heart Disease?

Congenital heart disease is defined as one or more problems with the structure of the heart that exist since birth. Congenital simply means that you are born with the defect. Although some congenital heart disease may not cause any problems. But, the complex ones will cause life-threatening complications. Congenital heart disease also known as congenital heart defect can change the way the blood flows or circulates through your heart.

What Is Early Vascular Ageing (EVA)?

Early Vascular Ageing or EVA was developed to establish primordial prevention by identifying individuals whose ageing path has been hastened either by inherent features, interaction with the environment or arterial exposure to several types of insults that has evolved to medial layer morphological changes.

It has been established as an independent risk marker for cardiovascular diseases, and reflects the uncorrelation between chronologic and biologic age of large arteries-attributing earlier the risk that a normal vascular ageing process had installed to occur later in several years.

There were 72 patients with congenital heart disease participated in the study whose brachial-ankle wave velocity or baPWV was evaluated. The early vascular ageing was defined as baPWV above the 95th percentile of values for age and gender.

Average baPWV was 1,280.6 cm/s. EVA was detected in 10 patients, generating a prevalence rate of 15.6%. As anticipated, baPWV was significantly raised in those with vs without EVA (1,846.5 vs 1,175 cm/s).With single regression analysis showed that age, systolic, and diastolic BB, pulse pressure, blood sugar, and glycated hemoglobin were all significant and positive associates of baPWV.

By using multiple regression analysis has confirmed the independent effect of systolic and age. Experts then performed logistic regression analysis to find potential indicators for EVA and found that systolic BP elevated its risk by over 10%. Similar effect was observed for diastolic BP, pulse pressure, blood sugar, glycated hemoglobin, and age.

 

Source: Hypertension Res 2021;44:1122-1128

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