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High Uric Acid Levels Increase Risk of Cardiovascular Diseases, Study Reveals

A study revealed that an increased uric acid levels seem to contribute to a higher risk of cardiovascular disease or CVD, such as coronary heart disease or CHD and stroke, among individuals with asymptomatic hyperuricemia, and this correlation is independent from hyperuricemia-related comorbidities.

High Uric Acid Levels Increase Risk of Cardiovascular Diseases, Study Reveals
Photo: Doctor Holding Urine Sample | InStyleHealth

What Is Hyperuricemia?

Hyperuricemia is defined as a health condition where a person has too much uric acid level in the blood. Having high uric acid levels can lead to several diseases, such as painful type of arthritis called gout. Elevated uric acid levels are also correlated with other health conditions such cardiovascular diseases, diabetes, and kidney disease.

What Causes Hyperuricemia?

Hyperuricemia takes place as a result of your body producing too much uric acid or getting rid of too little. When a person has a purine-rich diet, uric acid is created when purines – the chemical compounds that are found in certain foods and can be made by your body, break down.

Foods high in purine include the following:

Many people believe that hyperuricemia was the same as gout – a disease that affects the joint or a painful type of arthritis. However, when you have hyperuricemia, it does not necessarily result to having gout. As a matter of fact, most people with high uric acid levels don’t have any symptoms at all or asymptomatic.

Being overweight or obese, also puts a person at risk for hyperuricemia. Children and adolescents who are overweight, hyperuricemia is often accompanied by elements of metabolic syndrome: insulin resistance, chronic kidney disease, and high blood pressure.

Research covered 29,974 adults with average age of 47.2 years. Experts classified baseline serum uric acid beyond normal uric acid levels quarterly based on the distribution of healthy populations without CVD onset.

Following an average follow-up duration of 5.78 years, there was a total of 1,062 cardiovascular disease or CVD first-attack cases were recorded. Using a multivariate-adjusted Cox regression models revealed no significant correlation between asymptomatic hyperuricemia and incident CVD.

But the estimates revealed the 4th quartile of uric acid was correlated with a significantly elevated adjusted hazard ratio for CVD as compared with normal uricemia in the total cohort population, men, women, and individuals >50 years.

Instead, the age-standardized incidence risk of CVD in the 4th quartile of uric acid level was 2 to 3 times higher than the normouricemia population.

An analysis that excluded 14,464 individuals with diabetes, dyslipidemia, and hypertension, the elevated risk of CVD correlated with elevated uric acid was consistently noted in the asymptomatic hyperuricemia population in the absence of comorbidities.

Outcomes indicates that both renal and cardiovascular system could benefit from controlling the uric acid level under 7.2 mg/dl.


Source: Nutr Metab Cardiovasc Dis 2021;doi:10.1016/j.numecd.2021.08.043

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