Children with IBD May Benefit From Vitamin D Supplementation, Study Shows

A recent study indicates that supplementation with vitamin D seems to show benefits on children with inflammatory bowel disease or IBD.

Children with IBD May Benefit From Vitamin D Supplementation, Study Shows
Photo: Vitamin D Supplement | InStyleHealth


Researchers randomized 120 children with IBD and hypovitaminosis D to receive either oral vitamin D3 in a dose of 2,000 IU/day or placebo for 6 months, in order to evaluate the effect of vitamin D supplementation on disease activity, quality of life or QoL, inflammatory markers, and cytokines.

Supplementation effect on the IBD activity score was the primary endpoint, while secondary ones included QoL, inflammatory markers, cytokines, the safety of vitamin D, and the correlation of serum vitamin D levels with various clinical and laboratory variables.

The vitamin D supplementation resulted in a marked reduction in the IBD activity score in the vitamin D group comparing it with the placebo group. QoL also revealed significant improvements following vitamin D supplementation.

The inflammatory markers such as erythrocyte sedimentation rate, C-reactive protein, and fecal calprotectin and interleukin, and tumor necrosis factor-alpha significantly decreased in the vitamin D group, but, significantly increased following supplementation of the vitamins.

Furthermore, vitamin D revealed a significantly inverse correlation with the activity score, quality of life, levels of inflammatory markers, the frequency of hospitalization, and emergency department visits.

Researchers noted that vitamin D has anti-inflammatory and immune regulatory functions.

 

Source: J Clin Gastroenterol 2021;55:815-820

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