Vitamin D Reduces Risk of Developing Colorectal Cancer in Young Women

A study has recommended that increased intake of Vitamin D seems to reduce the risk of developing early-onset colorectal cancer and its precursor lesions in young women.

Vitamin D Reduces Risk of Developing Colorectal Cancer in Young Women
Photo: Vitamin D Sources | InStyleHealth


Research involved women enrolled in the Nurses’ Health Study II. A multivariable cox proportional hazards and logistics regression models were utilized to assess the correlation between the total vitamin D intake and the risks of colorectal cancer (CRC) and precursors diagnosed before 50 years old.

There was a total of 111 incident cases of early-onset colorectal cancer were documented, from 1991 to 2015, during 1,250,560 person-years of follow-up. These happened less frequently in the group of women with increased vitamin D intake. However, there were 1,439 cases of conventional adenoma and 1,878 cases of serrated polyp.

With the Cox models, the risk of developing early-onset colorectal cancer (CRC) was cut by half among women with vitamin D intake of >450 IU/day compared to those who had less <300 IU/day. Moreover, each 400 IU/day increase in intake presented a 54% risk reduction.

Chemo-preventive-effect against colorectal cancer was significantly pronounced with dietary sources of vitamin D (per 400 IU/day increase) than with supplemental vitamin D.

When it comes to colorectal cancer precursors, each 400 IU/day increase in vitamin D intake minimized the likelihood of conventional adenoma by 24% and serrated polyp by 15%.

 

Source: Gastroenterology2021;doi:10.1053/j.gastro.2021.07.002

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