A study has recommended that increased intake of Vitamin D seems to reduce the risk of developing early-onset colorectal cancer and its precursor lesions in young women.
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Research involved women enrolled in the Nurses’ Health
Study II. A multivariable cox proportional hazards and logistics regression
models were utilized to assess the correlation between the total vitamin D
intake and the risks of colorectal cancer (CRC) and precursors diagnosed before
50 years old.
There was a total of 111 incident cases of early-onset
colorectal cancer were documented, from 1991 to 2015, during 1,250,560
person-years of follow-up. These happened less frequently in the group of women
with increased vitamin D intake. However, there were 1,439 cases of conventional
adenoma and 1,878 cases of serrated polyp.
With the Cox models, the risk of developing early-onset
colorectal cancer (CRC) was cut by half among women with vitamin D intake of >450
IU/day compared to those who had less <300 IU/day. Moreover, each 400 IU/day
increase in intake presented a 54% risk reduction.
Chemo-preventive-effect against colorectal cancer was significantly
pronounced with dietary sources of vitamin D (per 400 IU/day increase) than
with supplemental vitamin D.
When it comes to colorectal cancer precursors, each
400 IU/day increase in vitamin D intake minimized the likelihood of conventional
adenoma by 24% and serrated polyp by 15%.
Source: Gastroenterology2021;doi:10.1053/j.gastro.2021.07.002