Using Testosterone Therapy and Statins Concomitantly Protects Against High-Grade and Advanced Prostate Cancer

A study has discovered that men using testosterone therapy or TTh and statins concomitantly seems to have lower odds of developing high-grade and advance stage prostate cancer, and this benefit is especially pronounced among White and Black men.

Using Testosterone Therapy and Statins Concomitantly Protects Against High-Grade and Advanced Prostate Cancer
Photo: Male Patient with Medical Professional | InStyleHealth


Research analysis covered 74,181 White, 9,157 Black, and 3,313 Hispanic men diagnosed with prostate cancer. Experts determined pre-diagnostic prescription of TTh and statins. Weighted multivariable-adjusted conditional logistic and Cox proportional hazards models were used to assess the concurrent use of the two medications in relation to the incidence of prostate cancer.

The incidence of prostate cancer was inversely correlated with either TTh or statins. Similar findings were observed for high-grade and advanced prostate cancer.

Using testosterone therapy and statins simultaneously, revealed a greater protection against the incidence of prostate cancer, as well as high-grade and advanced disease. The correlations remained significant among White and Black men only. For the Hispanic men, statins were correlated with prostate cancer-specific mortality.

Current data recommends a potential interaction between TTh and statin, with an additive effect on incident and aggressive prostate cancer in men of different racial and ethnicity. Further studies are required to establish the independent inverse correlation of TTh and the joint inverse correlation of TTh plus statins on the risk of prostate cancer in understudied populations, according to experts.

 

Source: Cancer Prev Res 2021;doi:10.1158/1940-6207.CAPR-21-0040

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