Tofacitinib and Ixekizumab the Most Effective Treatments for Nail Psoriasis, Study Finds

Small molecule inhibitors and biologic drugs show that tofacitinib and Ixekizumab are the most effective treatments for nail psoriasis in 10 to 16 weeks and 24 to 26 weeks, correspondingly, based on the systematic review and network meta-analysis of studies.

Tofacitinib and Ixekizumab the Most Effective Treatments for Nail Psoriasis, Study Finds
Photo: Nail Psoriasis | InStyleHealth


Researchers noted that various systemic immunomodulating therapies have been investigated to treat nail psoriasis, but the efficacy remains unclear.

Experts identified eligible studies in online databases until 10th March 2020, in order to resolve this. A network meta-analysis was conducted with surface under the cumulative ranking curve of improvement in nail score, as well as 100% improvement of Nail Psoriasis Severity Index or NAPSI to evaluate the efficacy of small molecule inhibitors and biologics.

There were 39 studies with 13 treatment arms, which involved a total of 15,673 patients with nail psoriasis, met the eligibility criteria. Use of tofacitinib and Ixekizumab provided the most improvement in nail score at 10 to 16 weeks and 24 to 26 weeks, accordingly.

Of all the treatments under study, Ixekizumab revealed the best efficacy for 100% improvement of the Nail Psoriasis Severity Index.

Notably, this systematic review and network meta-analysis was limited by insufficiency of eligible data and absence of long-term follow-up data, the researchers noted.

 

Source: J Am Acad Dermatol 2021;85:135-143

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