Statin and Omega-3 Supplement Combination Improves Coronary Plaque Regression, Study Reveals

A recent study reveals that combination of omega-3 supplements and statin therapy appears to improve coronary plaque regression, leading to lower risks of cardiovascular events.

Statin and Omega-3 Supplement Combination Improves Coronary Plaque Regression, Study Reveals
Photo: Statin and Omega-3 Combination | InStyleHealth


Sourcing from databases of PubMed, Embase, and Cochrane, experts gathered eight eligible studies that utilized various imaging techniques to assess the coronary atherosclerotic plaques. Statin’s effect alone was compared with the combination with omega-3 supplements.

Cumulative sample involving 803 participants, where 52.4% received the combination therapy, while 47.6% were given the monotherapy control. The pooled analysis of 5 randomized controlled trials or RCTs revealed that the combination of statins and supplement significantly slowed the progression of coronary plaque volume.

There were 6 studies that provided evidence regarding lipid volume, of which 2 were RCTs. Omega-3 and statin combination significantly delayed the progression of lipid volume of coronary plaques relative to monotherapy.

Regarding blood chemistry, the combination therapy intervention also led to significantly lower levels of high-sensitivity C-reactive protein. However, no such effect was reported for high- and low- density lipoprotein cholesterol concentrations.

Researchers said that omega-3 combined with statins is superior to the statin treatment group in stabilizing and promoting coronary plaque regression and may help to further reduce the occurrence of cardiovascular events.

 

Source: Am J Cardiol 2021;151:15-24

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