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Genes Drive Allege Contribution to Increased Inflammation in Depression

A recent study has revealed that regulation of eating and smoking habit, instead of an autoimmune genetic predisposition, drives the alleged contribution of genes to an increased inflammation in depression.

Genes Drive Allege Contribution to Increased Inflammation in Depression
Photo: Depression in Adults | InStyleHealth

Moreover, linkage between depression and increased inflammation even after full adjustment reveals either the presence of yet unknown or unmeasured psychosocial and clinical confounding factors or that a core biological relationship between the two exists independently from confounders, according to researchers.

Case-controlled study covered 26,894 individuals with a lifetime diagnosis of major depressive disorder from the Composite International Diagnostic Interview and 59,001 controls with no mental disorder and had not taken any antidepressant treatment.

Researchers then fitted linear regression models of log C-reactive protein or CRP to regress out the effects of age, gender, body mass index, and smoking, as well as to test whether the polygenic risk scores or PRS for major depression associated with log CRP level and whether the correlation between log CRP and major depression persisted following adjustment for early-life trauma, socioeconomic status, and self-reported health matters.

The participants with depression had significantly higher CRP levels than control participants (2.4 vs 2.1 mg/L). Additionally, more participants than controls had CRP levels >3 mg/L (21.2% vs 16.8%), which indicated low-grade inflammation.

PRS for depression significantly associated with log CRP levels; however, this correlation did not remain significant following the adjustment for BMI and smoking. Moreover, the correlation between depression and increased log CRP level markedly reduced but remained significant following the adjustment for clinical and sociodemographic factors.


Source: Am J Psychiatry 2021;178:522-529

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