Vitamin D and Omega-3 Supplements Have Favorable Effects In Prostate Cancer Patients

A study has revealed that intensive nutritional intervention with vitamin D and omega-3 polyunsaturated fatty acids or PUFA seems to have favorable effects in prostate cancer patients managed with active surveillance.

Photo: Vitamin D Supplements | InStyleHealth


Research involved 68 men with very-low or low-risk prostate cancer. They adhered to a specific dietary regimen that excluded animal-based products and foods containing omega-6 PUFAs. Aside from this, the patients received a supplement regimen that comprised omega-3 PUFAs 720mg (three times daily), curcumin 2,000mg (once daily), vitamin D3 with dose adjusted to achieve serum level of 60 ng/ml, and vitamin B-complex, 1,000mg (four times weekly).

The patients underwent evaluations, including periodic monitoring of prostate-specific antigen or PSA, serum vitamin D, and PUFA levels. They also attended frequent follow-up with a nutritionist, during which they completed a food frequency questionnaire. An interval prostate biopsy was conducted as clinically indicated and/or at 9 months.

Average PSA slope was 0.11 ng/mL/month, while the average vitamin D serum levels were 4.65 ng/mL/month.

The nutritional supplementation was correlated with a downward PSA trend, especially among patients with higher initial vitamin D levels.

Furthermore, all 55 patients who underwent follow-up biopsy showed no signs of disease progression.

Regarding safety, there were 3 patients who had loose bowel movements that required omega-3 and or curcumin dose adjustments.

According to researchers, more studies are warranted to establish the benefits of vitamin D and omega-3 PUFA supplementation in men on active surveillance for prostate cancer.

 

Source: Urology 2021;doi:10.1016/j.urology.2021.04.050

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