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Premature Myocardial Infarction Risk Factors Modifiable with Interventions, Study Reveals

A study has revealed according to the results of a systematic review and meta-analysis, that premature myocardial infarction or MI is correlated with risk factors such as dyslipidemia and obesity among others, that can be modified with interventions.

Photo: Premature Myocardial Infarction | InStyleHealth

Experts accessed online databases for observational studies assessing the correlation of at least one risk factor (e.g., demographic characteristics, lifestyle factors, clinical risk factors, or biomarkers) with premature myocardial infarction which occurred in men aged 18-55 years and women aged 18-65 years.

Research generated 35,320 articles covering 12.7 million participants. Of which, the experts identified 19 risk factors from 77 studies across 58 countries.

Men had about a two-fold greater likelihood of developing premature MI compared with women. Risk of premature MI was especially high in the presence of a family history of cardiac disease.

The other factors correlated with premature MI were modifiable. These factors included current smoking, diabetes mellitus, dyslipidemia, hypertension, and higher body mass index.

Biomarkers such as total cholesterol levels >200 mg/dL, triglyceride levels >150 mg/dL, and high-density lipoprotein cholesterol levels <60 mg/dL revealed about two- to three-fold risk increase.

Outcomes highlighted the need to develop interventions at the person, population, and policy levels to reduce the burden of the said risk factors and of premature myocardial infarction according to experts.


Source: Mayo Clin Proc Innov Qual Outcomes 2021;10.1016/j.mayocpiqo.2021.03.009

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