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Packed Red Blood Cells Transfusion Increases Risk of Kidney Injury in Infants, Study Finds

A recent study has discovered that transfusion of packed red blood cells in infants may trigger a slight and transient inflammatory status, signaled by an increase in levels of the inflammatory marker kidney injury molecule-1 or KIM-1.

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Research involved 34 infants whose urinary KIM-1 levels were assessed before and 6, 12, and 24 hours after the packed red blood cells transfusion. Blood transfusions associated with significant changes in the natural log of KIM-1 concentrations over time.

Prior PRBC transfusion, the median KIM-1 concentration was 2,270 pg/mg, which peaked 6-12 hours after transfusion, reaching a high of 3,300 pg/mg. After 24 hours transfusion, urinary KIM-1 plummeted back to 2,240 pg/mg, which was not significantly different from the pre-transfusion levels.

With multivariable analysis adjusted for pre-transfusion KIM-1 concentrations and the volume of blood received confirmed that PRBC transfusions significantly associated with the significant changes in urinary KIM-1 concentrations over the three post-transfusions time points.

Current results reveal “at timeline of when KIM-1 levels peak and how long it takes for them to return to the pre-transfusion status. This timeline may help in further evaluating the pathophysiology of transfusion-associated organ injury,” according to the researchers.

There will be future researches, researchers said, may elect to study if blood transfusions negatively influence renal artery perfusion. KIM-1 as an inflammatory marker may be considered in future studies evaluating the responses of the body to different transfusion volumes.


Source: Sci Rep 2021;11:11690

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