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Mediterranean Diet Lowers Cardiovascular Risk Among Antihypertensive Drug Users

A study suggests that following a Mediterranean diet lowers the risk of initiating or increasing antihypertensive medication in an older population at high cardiovascular risk and reduces CV risk among antihypertensive drug users.

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Researchers determined whether participants randomized to an intervention with a Mediterranean diet enriched with extra-virgin olive oil or nuts, relative to a low-fat control diet, disclosed differences in the risk of initiating antihypertensive medication in non-users at baseline and escalating therapy in those using one, two, or three drugs at baseline.

Furthermore, researchers sought to determine whether allocation to Mediterranean diet modified the relation between antihypertensive drug use and incident cardiovascular events.

Participants assigned to Mediterranean diet interventions had a lower risk of initiating antihypertensive therapy (5-year incidence rates: 43% in the Mediterranean diet vs 47.1% in the control diet, in a model that was adjusted for age, gender, and recruitment site).

For those individuals on two antihypertensive drugs at baseline in the Mediterranean diet intervention enriched with extra-virgin olive oil revealed a reduced risk of therapy escalation relative to those in the control diet (5-year incidence rates: 20.1% vs 22.9%).

Moreover, the Mediterranean diet intervention weakened the correlation between antihypertensive therapy at baseline and incidence of major adverse cardiovascular events.


Source: J Hypertens 2021;39:1230-1237

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