Greater Adherence to Healthy Dietary Patterns Promotes Healthy Ageing in Older Adults

A study reveals that greater adherence to a healthy dietary pattern and a lower inflammatory potential of diet may decrease concentrations of growth differential factor or GDF-15 in older adults, which suggests that improving one’s diet quality may help reduce inflammation and promote healthy ageing.

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Researchers said that, “GDF-15 is a biomarker for ageing and chronic disease burden that may capture the anti-inflammatory and antioxidant effects attributed to healthy diets.”

The cross-sectional data were obtained from 2,501 older adults participating in the Seniors-ENRICA-2 study. Researchers derived 4 diet indices from habitual food consumption estimated with a validated diet history: Mediterranean Diet Adherence Screener or MEDAS, Alternate Healthy Eating Index – 2010 or AHEI-2010, Dietary Approaches to Stop Hypertension or DASH, and Dietary Inflammatory Index or DII.

Using linear regression models, which was adjusted for risk factors and biomarkers correlated with chronic disease, to analyze the correlations of the diet indices with GDF-15 concentrations.

There was a clear dose-response correlation noted between all dietary patterns and serum GDF-15 concentrations. In the diet indices, average reductions in GDF-15 per 1-SD increment were 1.6% for MEDAS, 2.1% for AHEI-2010, and 1.6% for DASH, while an average GDF-15 increase of 1.7% was observed in DII.

The analyses that excluded fruit and vegetable components for the diet indices unveiled that the correlations persisted for MEDAS and AHEI-2010; however, it is weakened for DASH. Outcomes were similar in analyses excluding participants with CVD or cardiovascular disease and/or diabetes.

 

Source: Am J Clin Nutr 2021;113:1619-1626

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