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Chronic Liver Disease Not A Comorbid Condition of COVID-19, Study Finds

A recent study has discovered that chronic liver disease or CLD does not seem to be a strong comorbid condition of the novel coronavirus disease (COVID-19).

Photo: Chronic Liver Disease | InStyleHealth

Experts retrospectively evaluated the data of 1,439 COVID-19 patients with average age of 55.2 years, where 50.2% were men, consecutively hospitalized between March 16 and April 23, 2020. Characteristics and outcomes were compared between those with and without CLD. Postmortem liver evaluations in eight critically ill patients were also conducted.

There were 47 patients identified to have CLD, generating an overall prevalence rate of 3.3%. CLD frequency did not statistically differ among patients who had critical vs non-critical COVID-19.

Frequency of acute liver injury similarly did not differ between CLD and non-CLD patients, nor did overall survival and time to mechanical ventilation or intensive care admission.

The postmortem studies further unveiled that CLD was not a significant comorbidity of COVID-19. The histological assessments revealed that variable degrees of lymphocytic portal triaditis and of central vein outflow obstruction and injury, as well as focal fibrin thrombi were the most common findings. Chronic liver disease, such as cirrhosis, steatosis, and chronic hepatitis, was absent in all eight patients.

A multivariable cox regression identified age, hypertension, cardiovascular disease, malignancy, and liver injury as significant correlates of clinical findings in COVID-19 patients. Chronic liver disease failed to achieve significance.


Source: Sci Rep 2021;11:11734

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