Severe Atopic Eczema Increases Mortality Risk Among Adults, Study Shows

A recent study showed that very severe and predominantly active atopic eczema appears to increase mortality risk among adults.

Photo: Severe Atopic Eczema | InStyleHealth


Experts conducted a population-based matched group study including 526,736 atopic eczema patients with average age of 42.3 years where 58.5% were women, and 2,567,872 matched controls with an average age of 41.7 years where 58% were women. All participants in the study were followed for a median of 4.5 years.

Using the cox regression analysis, it showed limited evidence of a correlation between atopic eczema and all-cause mortality, though there seemed to be signals of interaction with infections, and diseases of the genitourinary system.

Particularly, researchers detected a potential intervening effect of disease severity. Among the participants, 34,610 patients, corresponding to 187,910 years of follow-up time, were believed to have severe atopic eczema, there were 4,446 of them have died.

On the other hand, statistical analysis revealed significant interactions between death due to various causes and severe versus no atopic eczema. For example, mortalities due to infections were nearly 3 times as likely to occur among patients with severe diseases.

Furthermore, mortalities due to respiratory and genitourinary diseases were more than twice as likely in those with severe disease. The risk of all-cause death was raised by over 60%.

 

Source: J Allerg Clin Immunol 2021;147:1753-1763

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