Ongoing Use of Furosemide Reduces Risk of Hyponatremia Hospitalization, Experts Suggest

A study suggests that patients with ongoing use of furosemide are at reduced risk of being hospitalized due to hyponatremia. Furthermore, this type of diuretic may have a protective effect according to experts.

Photo: Diuretic Medication | InStyleHealth


The study sought to investigate whether this association vary by types of nonthiazide diuretics, since diuretics have been linked to hyponatremia. Experts looked at a total of 11,213 patients hospitalized with a principal diagnosis of hyponatremia and 44,801 matched controls.

Utilizing the logistic regression to assess potential correlations, with adjustments for multiple confounders. The analysis was also stratified based on thiazide use.

Risk of hospitalization for hyponatremia had a positive correlation with amiloride use and spironolactone use, as well as an inverse correlation with furosemide.

Protective correlation with other drugs as stratified by use were as follows: 3.55 for newly initiated spironolactone, 1.75 for ongoing spironolactone use, and 1.62 for ongoing amiloride use.

Results showed that while furosemide may be protective or beneficial against hyponatremia, spironolactone and amiloride may both contribute to it, with this effect being most prominent early in treatment, experts said.

 

Source: Clin Endocrinol 2021;doi:10.1111/cen.14497

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