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Healthy Lifestyle Promotes Normal Glucose Regulation in People with Prediabetes, Study Finds

A recent study has found that healthy lifestyle factors promote the reversion to normal glucose regulation in people with prediabetes. Although such factors cannot explain variability in reversion in different subtypes of prediabetes.

Photo: Healthy Lifestyle Promotes Normal Glucose Regulation | InStyleHealth

Utilizing the data from the Cohort study in Primary Health Care on the Evolution of Patients with Prediabetes, the researchers covered 1,1184 individuals with an age range of 30-74 years old whom are deemed to be prediabetic. Depending on the definition, participants were divided into 3 prediabetic groups: group 1 (fasting plasma glucose [FPG] 100-125 mg/dL), group 2 (glycated hemoglobin [HbA1c] 39-47 mmol/mol), and group 3 (both FPG and HbA1c impaired).

In general, 165 participants reverted to normal glucose regulation by year 3, generating a reversion rate of 17.4%. Stratifying by type of prediabetes, reversion was highest in group 1, with a rate of 31%. This was followed by group 2 (24.4%), and distantly, by group 3 (7.9%).

With the utilization of multivariate logistic regression analysis, it revealed that lifestyle factors were important indicators of reversion. Those who were normal weight, for example, were nearly twice as likely to revert to normal glucose level or normoglycemia than their overweight/obese counterparts.

Also, those participants who were more physically active, had better adherence to the Mediterranean diet, and had no abdominal obesity were more likely to revert.

The type of prediabetes was also an important factor for reversion, such that participants in groups 1 and 2 were significantly more likely to revert than their group 3 counterparts. Particularly, adjusting the models for lifestyle factors did not lessen the significant impact of prediabetes subtype on reversion, suggesting that other factors may account for this variability.


Source: Sci Rep 2021;11:9667

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