Does Coffee Consumption Affect Inflammation and Lower Cardiovascular Mortality Risk? Find Out What Experts Say

There is no conclusive evidence that the anti-inflammatory effect of coffee plays a major role in the reduction of all-cause death noted in observational studies according to a systematic review of randomized controlled trials or RCTs.

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According to the researchers that coffee is one of the most widely consumed beverages globally. A substantial number of observational data suggest an inverse relationship between coffee consumption and the risk for cardiovascular diseases.

The review specifically evaluated the impact of coffee on inflammatory biomarkers as a potential mechanistic basis for the above observation. Bibliographic databases were systemically assessed, including PubMed (NCBI), Embase (Elsevier), Cinahl (EBSCO), Web of Science (Clarivate Analytics), Cochrane Central Register of Controlled Trials (EBSCO), and CAB Abstracts (Clarivate Analytics).

Researchers looked for RCTs that evaluated the effect of drinking coffee on inflammatory markers of cardiovascular risk.

There were 1,631 studies were classified from the electronic databases. There were 40 full-text documents were evaluated after removing duplicate records and ineligible studies, of which 17 were found to be eligible for further analysis.

Boiled coffee, based on the results, appeared to increase total and low-density lipoprotein cholesterol and apolipoprotein B. Although, no similar effect was noticed for filtered coffee. Particularly, one study demonstrated a marked elevation in levels of blood interleukin 6 among individuals who consumed caffeinated coffee as opposed to those who did not drink coffee.

Experts said that the body of evidence relating coffee consumption to specific candidate biomarkers is weak and limited to small studies of brief duration. Information on well-known biomarkers, including tumor necrosis factor-alpha, leptin, homocysteine, and fibrinogen, is mostly lacking.

Aside from caffeine, coffee contains bioactive substances, such as diterpenes, polyphenols, and melanoidins.

 

Source: Am J Med 2021;134:626-636.E2

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