Diets High in Acidogenic Foods are at High Risk of Developing Pancreatic Cancer, Study Suggests

A recent study suggested that individuals with diets high in acidogenic foods are at high risk of developing pancreatic cancer.

Photo: Anatomy of Pancreas | InStyleHealth


The modern western diets are typically loaded with acid-forming foods. Human and in vitro studies revealed a potential link between dietary acid load and cancer risk.

Current population-based study comprised 95,708 American adults. Dietary acid load was evaluated using potential renal acid load or PRAL and net endogenous acid production or NEAP; the greater the value, the higher the dietary acid load.

There was a total of 337  pancreatic cancer cases occurred over 848,534.0 person-years of follow-up. Fully adjusting cox regression models showed that PRAL score had a positive correlation with the risk of pancreatic cancer. Comparing with lowest quartile, the highest PRAL score quartile contributed to a 73% risk increase.

For a subgroup analysis, the positive correlation between PRAL score and the risk of pancreatic cancer was stronger among younger than older participants. Similar outcomes were seen for the NEAP score.

According to experts, the current epidemiologic study is said to be the first of its kind, and the findings point to the possibility that lowering dietary acid load may play an important role in the prevention of pancreatic cancer. Nonetheless, additional studies in other populations and settings are warranted to validate the data gathered.

 


Source: Cancer Epidemiol Biomarkers Prev 2021;30:1009-1019

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