Concomitant Use of Aspirin and Statin Leads to Greater Reduction in Liver Cancer Risk, Study Reveals

A recent study revealed that daily aspirin use already shows a protective signal against hepatocellular carcinoma (HCC) and concomitant use of statin can lead to a greater risk reduction without increasing the incidence of esophageal variceal hemorrhage.

Photo: Daily Aspirin Use | InStyleHealth


Research evaluated the effect of concurrent use of aspirin and statin on the incidence of HCC, as well as to identify if it posed a risk of variceal hemorrhage (VH). The analysis included a prospective group of 521 patients with liver cirrhosis.

Aspirin use alone yielded a reduction in the incidence of HCC both in the univariate and multivariate models.

Notably, the risk of HCC further reduced when aspirin and statin were taken concomitantly. The correlation remained statistically significant in the multivariable model.

Regarding safety, daily aspirin users were not at increased risk of VH compared with non-users.

Findings of the study indicated a potential beneficial interaction between aspirin and statin in relation with HCC risk. More studies are needed to validate the current data according to researchers.

 

Source: J Clin Gastroenterol2021;doi:10.1097/MCG.0000000000001546

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