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Sufentanil Ropivacaine Relieves Labor Pain Better Than Nalbuphine Ropivacaine, Study Shows

A study has shown the kappa-opioid receptor agonist nalbuphine appears to provide subpar analgesic effects compared with the mu receptor agonist sufentanil when added to ropivacaine in the management of labor pain in women.

Photo: Pregnant Woman in Hospital | InStyleHealth

There was a total of 180 pregnant women who were about to give birth and requesting pain reliever during labor were randomized to receive nalbuphine or sufentanil. Five minutes after the initial dose, the women were given 10 mL of 0.1% ropivacaine plus either 0.3 mg/mL nalbuphine solution or 0.3 µg/mL sufentanil.

Initial findings of the duration of analgesia, the time to the first requirement for additional medication, was significantly shorter on nalbuphine than on sufentanil.

Moreover, ropivacaine dose per hour in the nalbuphine group was significantly greater than in the sufentanil group.

There were no serious undesirable events directly correlated with the analgesics seen either in the mother or in the fetus.

Throughout epidural labor analgesia, the addition of a small dose of opioids has the potential to enhance the local analgesic effect, reduce the dose of local anesthetic required, and minimize motor blockade. Earlier reports cite that kappa-opioid receptor agonists are more effective than mu receptor agonist for the treatment of visceral pain. Although, the present study suggests that sufentanil may be preferable to nalbuphine for women requesting pain reliever during labor.

For complete details of the study, you may click here.


Source: J Clin Pain 2021;doi:10.1097/AJP.0000000000000928
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