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Study Suggests Careful Use of Ammonium Chloride in COVID-19 Therapy

A recent study has suggested that while the addition of ammonium chloride to standard care falls short of significantly reducing mortality in COVID-19, it can lead to shorter time to recovery.

Photo: Ammonium Chloride | InStyleHealth

The quaternary ammonium compounds have shown notable antiviral effects and may be of use against SARS-CoV-2 infections. Based on the recent study, a team of experts tested whether adding ammonium chloride to standard treatment regimen for COVID-19 would improve the result of the infection.

Research had randomly selected a total of 120 patients to receive standard care plus either diphenhydramine and ammonium chloride, a 10-ml oral syrup 3x a day for 7 days or diphenhydramine alone – a 10 ml oral syrup three times a day for 7 days as placebo. Standard treatment regimen included concomitant atazanavir, 300 mg taken orally twice a day in hospitalized patients and methylprednisolone – 1 g/day for 3 days in patients admitted to intensive care unit (ICU).

Primary result of all-cause mortality within 30 days of randomization did not significantly differ between two treatment groups.

On the other hand, patients who received ammonium chloride were more likely to have a shorter recovery time and lower viral burden compared with those who received the control treatment.

Results of the study promotes the careful addition of ammonium chloride to standard of care for COVID-19 patients.


Source: Int J Infect Dis 2021;doi:10.1016/j.ijid.2021.04.043

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