Patients on Peritoneal Dialysis Benefits Probiotics Supplementation, Study Reveals

A recent study has revealed that patients on peritoneal dialysis (PD) may benefit from probiotic supplementation, with partial improvements in malnutrition and health-related quality of life.

Photo: Probiotics Improves Health Related Quality of Life | InStyleHealth


Experts randomly selected 116 patients undergoing PD to receive either a probiotic intervention, given daily at a dose of 1 x 109 CFU, or a no-intervention control. The trial duration lasted for 2 months. Results included biochemical indicators, physical measurements, and Short Form 36 (SF-36) scores.

Following the treatment, levels of high-sensitivity C-reactive protein, interleukin-6, and low-density lipoprotein cholesterol were all significantly lower in the probiotic group as opposed to controls. On the other hand, body mass index, high-density lipoprotein, and fat mass did not differ between the two groups.

Furthermore, experts also observed improvements over time in terms of upper arm circumference, albumin levels, and triceps skinfold thickness, though between-group comparisons failed to attain statistical significance.

Meanwhile, the HRQoL or Health-related Quality of Life, experts showed that physical functioning was better in the probiotic group than controls after 2 months, as was social functioning. Changes in other domains such as vitality, body pain, mental health, among others were not different between the two groups.

Experts said that the results of this study suggest that probiotic supplementation in patients undergoing PD is safe and well tolerated. The malnutrition of patients undergoing PD was improved after probiotic supplementation. Moreover, the scores of physical functioning and social functioning increased in the probiotic group. However, larger studies are needed to determine whether probiotics lead to significant improvements in clinical outcomes in patients undergoing PD.

 

Source: J Ren Nutr 2021;31:199-205

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