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Non-alcoholic Fatty Liver Disease Increases Glucose Intolerance Risk, Study Finds

A recent study has discovered that fatty liver disease (FLD) is a risk factor for the onset of impaired fasting glucose (IFG) among non-alcoholic adults.

Photo: Human Organ - Liver | InStyleHealth

The study evaluated 8,664 individuals who underwent at least two annual health check-ups. Individuals were divided into 5 groups according to gender-specific alanine aminotransferase (ALT) levels, FLD status, and alcohol intake; each group was further subdivided according to gender. Research result was the onset of IFG, which is defined as a fasting plasma glucose (FPG) level >6.11 nM.

Non-alcoholic men with normal ALT level but with FLD were >50% more likely to develop IFG than the reference group. Amon the non-alcoholic men with FLD and elevated ALT, the excess risk of IFG was almost 80% higher.

Experts also saw an increased IFG risks in non-alcoholic men with elevated ALT, but no FLD. Although, no excess IFG risk was detected in any alcoholic subgroup of men.

For women, using multivariate analysis, it revealed that the only subgroup correlated with significantly higher IFG risk was that with non-alcoholic normal ALT levels with FLD.

According the researchers that the present study revealed that FLD in non-alcoholic patients increased the risk of developing glucose intolerance, even if the ALT level was normal. Therefore, regardless of their ALT levels, non-alcoholic patients with FLD require care to prevent the onset of pre-diabetes and reduce the risk of the development of diabetes and cardiovascular disease (CVD).

For complete details of the clinical study, click here.


Source: J Diabetes Investig 2021;doi:10.1111/jdi.13548
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