Micronized Progesterone Improves Sleep Outcomes Among Postmenopausal Women, Study Shows

According to a study that a micronized progesterone has been shown to improve sleep outcomes, especially among postmenopausal women, in randomized controlled trials (RCTs).

Photo: Micronized Progesterone | InStyleHealth


Preclinical data has shown progesterone metabolites improve sleep parameters through positive allosteric modulation of the γ-aminobutyric acid type A receptor.

 – Researchers

Databases of Medline, Embase, PsycInfo, and the Cochrane Central Register of Controlled Trials were examined using preferred reporting items for systematic review and meta-analysis guidelines. Researchers identified RCTs of micronized progesterone treatment on sleep outcomes up to 31st March 2020 and utilized a random effects model for quantitative analysis.

There were 9 RCTs involving 388 participants were included in the meta-analysis. An additional unpublished trial was also discovered. Based on the studies, 8 enrolled postmenopausal women. Comparing with placebo, micronized progesterone yielded in improvements of various sleep parameters as measured by polysomnography, including total sleep time and sleep onset latency, although inconsistent studies.

With the meta-analysis of 4 RCTs, micronized progesterone enhanced sleep onset latency but not total sleep time or sleep efficiency.

The sleep-reported sleep outcomes improved in most trials. But, concomitant estradiol administration and improvement in vasomotor symptoms had limitations to the conclusions in some studies.

Further research could evaluate the efficacy of micronized progesterone monotherapy using polysomnography or validated questionnaires in larger cohorts.

– Researchers

For complete details of the clinical research, you may click here.


Source: J Clin Endocrinol Metab 2021;106:942-951

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