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Low-dose Aspirin Reduces Pre-eclampsia Risk During Pregnancy, Study Reveals

A recent study reveals that among pregnant women, early initiation of low-dose aspirin largely reduces the incidence of pre-eclampsia and related neonatal outcomes without increasing the risk of bleeding.

Photo: Low-dose Aspirin During Pregnancy | InStyleHealth

A low-dose aspirin has been used as a preventive measure against pre-eclampsia, so experts looked at existing literature to carefully investigate the maternal and neonatal outcomes related to the prophylactic use of aspirin during pregnancy by utilizing a stratification procedure.

Meta-analysis covered the placebo-controlled randomized trials with sufficient raw data and published in English. Review articles, editorials, case studies, conference abstracts, and non-placebo-controlled studies were excluded.

There was a total of 35 placebo-controlled randomized trials with 46,568 pregnant women who met the criteria for inclusion. Collected data showed that aspirin prophylaxis conferred a significant protection against the risk of pre-eclampsia, preterm birth, perinatal mortality, and intrauterine growth retardation. The said benefits did not come with an increased bleeding risk.

Notably, low-dose aspirin yielded a meaningful improvement in neonatal birth weight but did not reduce the risk of gestational hypertension.

For subgroup analysis, the use of prophylactic low-dose aspirin conferred the said benefits which is lower pre-eclampsia risk and enhanced birth weight and gestational age at delivery among women who initiated the treatment prior 20 weeks of gestation.

On the other hand, low-dose aspirin exerted little effect on pregnancy results. As such, further evaluation is warranted.

For complete details of the clinical study or meta-analysis, you may click here.


Source: Am J Prev Med 2021;doi:10.1016/j.amepre.2021.01.032

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