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Hormone Therapy Provides Nocturia Benefits for Menopausal Women, Study Shows

According to a study that the benefit of using hormone therapy for menopause seems to extend nocturia prevalence and bother.

Photo: Nocturia | InStyleHealth

What is nocturia?

Nocturia is defined as a medical condition in which one will wake up during the night because you have to urinate. Nocturia has certain causes like high fluid intake, sleep disorders, and bladder obstruction. Nocturia can be treated with certain activities, such as restricting fluids, and medications that can reduce symptoms of overactive bladder.

There is a total of 245 postmenopausal women volunteered in the study, they were grouped into four according to their choice of treatment: estrogen plus progesterone (E+P), estrogen only in those with a prior hysterectomy, tissue-selective estrogen complex (TSEC), and no treatment.

All of the patients have completed two standardized questionnaires before and after treatment – the International Consultation on Incontinence Questionnaire Nocturia Module and the Targeting the individual’s Etiology of Nocturia to Guide Outcomes (TANGO) – to assess nocturia and its causative factors.

The hormone therapy led to a significant reduction in the prevalence of nocturia occurring twice per night, from 27.7% to 16.4%. Based on further analysis, the reduction in nocturnal voiding frequency was greater for patients treated with E+P and TSEC.

Hormone therapy effect on nocturia was driven by a significant reduction in SLEEP sum score in patients treated with E+P and TSEC.

On the other hand, treatment with estrogen yielded a marked change in URINARY TRACT total score only, which could be explained by a decrease in urgency prevalence.

According to experts, additional studies are necessary to validate the current data presented in the research.


Source: Menopause 2021;doi:10.1097/GME.0000000000001741

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