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Hormone Replacement Therapy In Menopausal Women Increases Risk of Asthma, Study Finds

A study has discovered that the use of hormone replacement therapy (HRT) in menopausal women seems to contribute to an increased risk of developing asthma.

Photo: Hormone Replacement Therapy | InStyleHealth

Data from the Danish registers between 1995 and 2018 were used in the nested  case-control study. Medical experts described an asthma diagnosis as two redeemed prescriptions of inhaled corticosteroids within 2 years. However, HRT use was identified among those who had redeemed prescriptions of female gender hormones within 6 months.

Overall, there were 34,533 women with asthma and 345,116 controls without the condition were included in the analysis. The volunteers were between 40- and 65-years old women.

By using the multivariable conditional logistic regression models revealed that active HRT conferred a 63% elevated risk of new-onset asthma occurrence compared with non-use. The analysis, of course, was adjusted for age, household income, and educational level of the participants.

Moreover, among women with asthma, termination of HRT was correlated with greater possibility to eventually discontinue their asthma treatment.

Based on the findings, the medical experts emphasized the need for clinicians prescribing and women receiving HRT to be aware that new airway symptoms can develop, and discontinuation of the therapy should be taken into consideration.

For complete details of the study, click here.


Source: Chest 2021;doi:10.1016/j.chest.2021.01.054

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