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Familial Hypertension History Increases Risk of Vascular Stiffness, Study Reveals

A recent study has revealed that brachial-ankle pulse-wave velocity (baPWV) and femoral-ankle (fa)PWV are elevated in individuals with a history of familial hypertension. It is suggesting that increased central and peripheral arterial stiffness in susceptible individuals before hypertension onset.

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The researchers said, “Routine measurement of these parameters may allow for early intervention and risk stratification, especially in persons with a history of familial hypertension.”

What is familial hypertension?

Familial hypertension also known as genetic hypertension or pseudo hypoaldosteronism type 2, is a medical condition that is considered a rare inherited form of low-renin hypertension associated with hyperkalemia and hyperchloremic metabolic acidosis in patients with a normal glomerular filtration rate (GFR) .This monogenic form of arterial hypertension has excited new interest since the discovery of a new, unsuspected molecular pathway that is responsible for both the biochemical abnormalities and the increase in blood pressure (BP) observed.

The research involved 82 non-hypertensive individuals with an average age of 31.4 years old, were selected and interviewed regarding their medical and family history. The volunteers were then divided into two groups based on the history of familial hypertension and were measured for baPWV and faPWV. Through these measurements, carotid-femoral PWV was calculated.

From the total number of participants, 43.7% had a history of familial hypertension. No significant between-group differences were observed in other clinical or demographic characteristics. The participants with a history of familial hypertension presented with significantly elevated baPWV and faPWV.

Experts noted that, “Hypertension is the leading cause of cardiovascular disease and premature death. New methods for early detection of hypertension and its consequences can reduce complications arising from uncontrolled hypertension.”

Pulse-wave Velocity or PWV is a measure of arterial stiffness and has been recognized as an essential tool in evaluating the risk of cardiovascular complications. Although, PWV’s use in clinical or medical practice remains limited according to medical experts.

For complete details of the study, click here.


Source: J Hypertens 2021;39:627-632

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