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Enteral Vitamin D Treatment Fails for Cognitive Function Protection of Critically Ill Patients, Study Reveals

A study revealed that critically ill patients with Vitamin D deficiency do not appear to benefit from the enteral treatment with high-dose Vitamin D3 in terms of global cognition or executive function.

Photo: Enteral Vitamin D Treatment | InStyleHealth

Research randomized 95 vitamin-D deficient, critically ill patients to receive a single high-dose (540,000 IU) enteral treatment of vitamin D3 to 47 patients or placebo to 48 individuals shortly after hospital admission.

Efficacy outcomes were global cognition using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and executive function which is being assessed using a composite score derived from three Delis – Kaplan Executive Function System subscales.

Evaluations were facilitated at an average of 443 days after randomization and compared using multivariable proportional odds regression.

Findings revealed that enteral vitamin D3 treatment produced a significant improvement in neither global cognition nor executive function. Adjusted average RBANS score at follow-up was 79.6 in the vitamin D3 group vs 82.1 in the placebo group.

Similarly, the adjusted average executive function composite score was similar in the treatment groups, with an aOR of 0.72. For complete details of the clinical research, click here.


Source: Chest 2021;doi:10.1016/j.chest.2021.03.046

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