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Benzodiazepines May Worsen Delirium Risk in Patients with Acute Decompensated Heart Failure, Study Reveals

A recent study has revealed that patients with acute decompensated heart failure (ADHF), the use of anxiolytic benzodiazepines may worsen the risk of severe delirium.

Photo: Acute Decompensated Heart Failure | InStyleHealth

Carefully reviewing information from 650 treated ADHF patients, researchers looked for potential risk factors for delirium, including sociodemographic variables, intensive care needs, the use of mechanical ventilation, surgery, and comorbidities like depression, diabetes, and dementia. Medications for ADHF were also assessed. Delirium was diagnosed in accordance with the Confusion Assessment Method (CAM).

Throughout the study observation coverage, 59 patients experienced severe delirium, resulting in an incidence rate of 9.1%. Most common medications prescribed were diuretics (96.6%) and beta-blockers (68.8%); only 43 patients were given anxiolytic benzodiazepines.

Even with its low prescription numbers, the use of anxiolytic benzodiazepines was determined in multivariate logistic regression analysis as a significant risk factor for delirium.

Other risk factors identified included mechanical ventilation or noninvasive positive pressure ventilation, depression, male gender, and age.

Examining at discriminative models, experts further discovered that including the use of anxiolytic benzodiazepines as a factor could statistically improve the predictive ability of such models for delirium.

Researchers said that further investigations are warranted to determine whether avoiding the use of anxiolytic benzodiazepines decreases the incidence of delirium in patients with HF.


Source: PLoS One 2021

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