Age and Body Mass Index Affect Insulin Needs for Diabetes Patients, Study Reveals

A new study has revealed that age and body mass index or BMI affect the basal insulin needs for type 1 diabetes (T1D) patients.

Photo: Insulin Needs for Diabetes Patients | InStyleHealth


The research included 67 in-patients diagnosed with Type 1 diabetes. While confined in hospital, they received diabetic-friendly meals and underwent basal insulin adjustments to maintain stable blood glucose levels. Bolus insulin doses before meals were likewise adjusted to manage blood glucose. The total daily insulin dose (TDD) and the percent of total daily basal insulin (TBD) to TDD (%TBD/TDD) were calculated.

Based on the evaluation of the 3-day insulin requirements, it showed that the TDD was 33.0 units, while TBD was 7.0 units. The total bolus dose needed was 26.0 units. The resulting %TBD/TDD was 24.1%.

Researchers conducted the Pearson’s and Spearman’s rank correlation analyses to identify factors linked to %TBD/TDD. They discovered that BMI was directly and significantly correlated with %TBD/TDD, while age at examination and at diabetes onset showed inverse correlations.

By using the multiple regression analysis eventually confirmed the significant and independent roles of BMI and age at examination in affecting %TBD/TDD. Diabetes duration and serum levels of C-peptides had no impacts.

There are study limitations, however, included in its retrospective and observational design, small study size, single-center data resource, and limited generalizability.

According to researchers, it is important to set the %TBD/TDD on an individual basis while considering patient background characteristics, such as the BMI and age.

For complete and full details of the clinical research, you may click here.

 

Source: J Diabetes Investig 2021;doi:10.1111/jdi.13547

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