Statin Use Moderates Elevation in Triglyceride After a Fat Meal, Study Shows

A study shows that chronic statin medication moderates the elevations in triglyceride after a fat meal (e.g., incremental are under the curve of PPTG), decreasing the cardiovascular risk correlated with atherogenic dyslipidemia.

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On the other hand, exercise does not seem to reduce postprandial triglyceridemia (PPTG) in individuals with hypercholesteremic metabolic syndrome (MetS) relative to metabolically healthy (MetH) controls.

According to the authors, “Statin decreases PPTG by reducing the secretion or accelerating the catabolism of intestinal Apo B48.”

Researchers made a comparison on eight hypercholesteremic and overweight individuals with MetS to a group of eight MetH controls. Each group has undergone two PPTG testing, either 14 hours after a bout of intense exercise or without previous exercise. Additionally, individuals with MetS were evaluated 96 hours after withdrawal of their habitual statin medication to study for any effects on the medication.

Short period of exercise prior to the test meal did not decrease PPTG in MetS individuals; but it reduced PPTG by 46% in MetH controls.

For both trials either after a short period of intense exercise or without previous exercise, statin withdrawal in individuals with MetS led to a significant increase in PPTG, total cholesterol, and apolipoprotein, with no interference from exercise. Meanwhile, statin withdrawal did not affect Apo B100.

For complete details of the study, click here.

 

Source: Br J Clin Pharmacol 2021;87:955-964

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