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Sleep Disruption Fatigue Signals Increased Risk of Relapse after Hematopoietic Stem Cell Transplantation, Study Finds

According to a study that among patients who have undergone allogeneic hematopoietic stem cell transplantation (HCT), biobehavioral symptoms, such as sleep disruption and fatigue interference, may signal an increased risk of relapse and mortality over 6 years after HCT.

Photo: Sleep Disruption Fatigue | InStyleHealth

Research analysis involved 241 adults who received allogeneic HCT for a hematologic malignancy. They completed self-report measures of depression symptoms, sleep quality, and fatigue prior to HCT and 100 days following the procedure. The follow-up for clinical results lasted up to 6 years.

Utilizing the multivariable cox proportional hazard models controlled for patient demographic and medical characteristics revealed that the risk of mortality was independently correlated with high pre-HCT sleep disruption and greater post-HCT fatigue interference.

On the other hand, moderate pre-HCT sleep disruption came out as a risk factor for relapse.

The biobehavioral symptoms had no correlation with the incidence of chronic graft-versus-host disease (cGVHD).

Results indicate that the identified predictors of a heightened risk for 6-year relapse and mortality after HCT are responsive to treatment. By itself, they offer specific targets for intervention to improve HCT results.

For complete details of the study, click here.


Source: J Natl Cancer Inst 2021;doi:10.1093/jnci/djab032

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