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Sildenafil Treatment Improves Erectile Function Recovery After Radical Prostatectomy, Study Suggests

A study suggests that treatment with 100-mg sildenafil appears to be the best strategy to improve erectile function recovery rates after radical prostatectomy.

Photo: Male Patient with Doctor | InStyleHealth

Although, the on-demand dose of phosphodiesterase-5 (PDE5) inhibitors does not seem to be any better than placebo and must therefore not to be taken into consideration as penile rehabilitation strategy.

What is Prostatectomy?

Prostatectomy is surgical procedure of removing part or all of the prostate gland. The prostate gland is located in the male pelvis, just below the urinary bladder. This is the gland that surrounds the urethra, which is responsible for carrying the urine from the bladder to the p**s.

This procedure is used to treat a number of conditions affecting the prostate. It is most commonly used as a treatment for prostate cancer.

Experts systematically searched the databases of PubMed and Web of Science according to the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) extension statement for network meta-analysis. Researchers identified studies comparing the erectile function recovery rate and adverse events between penile rehabilitation treatment groups and the control group. Bayesian approach was utilized in the network meta-analysis.

There were 22 studies covering 2,711 patients were eligible for the analysis. Of the 16 different penile rehabilitation strategies and schedules compared with placebo, only pelvic floor muscle training and sildenafil 100 mg regular dose correlated with a significantly higher likelihood of erectile function recovery.

Certainty of results was moderate for 100 mg sildenafil regular dose was moderate and low for pelvic floor muscle training. With the sensitivity analysis, the regular high dose of PDE5 inhibitors regardless of type versus placebo was correlated with a higher likelihood of erectile function recovery with a moderate certainty. The on-demand doses of PDE5 inhibitors, on the other hand, were not more beneficial than the placebo.

Secondary results such as adverse events (AEs) were not subjected to analysis due to incomplete data in the literature, however, no serious AEs were found in any of the studies.

Although pelvic floor muscle training has been shown to be effective in increasing the erectile function recovery rate, well designed randomized controlled trials with larger sample sizes are needed to confirm the presented early results. 

– Researchers

For complete details of the study, click here.

Source: J Urol 2021;205:1018-1030

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