A recent study has shown that high variability in the ratio between triglycerides and high-density lipoprotein-cholesterol (TG/HDL-C) appears to increase the risk of diabetes.
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Researchers enrolled 45,911 patients with an average
age of 52.37 years, where 75.73% were men who had three triglycerides (TG) and
high-density lipoprotein-cholesterol (HDL-C) evaluations taken between years
2006 and 2011. The average real variability (ARV) was calculated, and patients
were grouped into tertiles of TG/HDL-C-ARV.
With an average observation period of 6.24 years, there
were 3,724 incident cases of diabetes mellitus were recorded. The 7-year
cumulative incidence rate was lowest in the bottom tertile of TG/HDL-C-ARC and
rose with each succeeding category.
Using the Cox proportional hazards model further revealed
a link between TG/HDL-C-ARV and diabetes risk. Comparative to the lowest category,
the risk of incident diabetes was higher by 16% and 38% in the second, and
third tertiles of TG/HDL-C-ARV, correspondingly.
While taken as a continuous variable, each standard
deviation increments in TG/HDL-C-ARC associated with a 4% increase in incident
diabetes risk. Abovementioned analyses were adjusted for potential variables, including
age, gender, body mass index, blood lipid profile, lifestyle factors, family
history, medications, and glucose history.
To the best of our knowledge, this was the first study to determine a positive correlation between TG/HDL-C ratio variability and new-onset diabetes in a large cohort. These findings were confirmed in sensitivity and subgroup analyses, suggesting that this relation was fairly universal.
Further epidemiological experimental research should be performed to confirm this finding and to gain a fuller understanding of the mechanisms linking visit-to-visit TG/HDL-C ratio variability and diabetes.
For complete details of the study, click here.
Source: J Diabetes Investig 2021;doi:10.1111/jdi.13536