High Triglycerides and High-Density Lipoprotein Cholesterol Variability Increases Risk of Diabetes, Study Shows

A recent study has shown that high variability in the ratio between triglycerides and high-density lipoprotein-cholesterol (TG/HDL-C) appears to increase the risk of diabetes.

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Researchers enrolled 45,911 patients with an average age of 52.37 years, where 75.73% were men who had three triglycerides (TG) and high-density lipoprotein-cholesterol (HDL-C) evaluations taken between years 2006 and 2011. The average real variability (ARV) was calculated, and patients were grouped into tertiles of TG/HDL-C-ARV.

With an average observation period of 6.24 years, there were 3,724 incident cases of diabetes mellitus were recorded. The 7-year cumulative incidence rate was lowest in the bottom tertile of TG/HDL-C-ARC and rose with each succeeding category.

Using the Cox proportional hazards model further revealed a link between TG/HDL-C-ARV and diabetes risk. Comparative to the lowest category, the risk of incident diabetes was higher by 16% and 38% in the second, and third tertiles of TG/HDL-C-ARV, correspondingly.

While taken as a continuous variable, each standard deviation increments in TG/HDL-C-ARC associated with a 4% increase in incident diabetes risk. Abovementioned analyses were adjusted for potential variables, including age, gender, body mass index, blood lipid profile, lifestyle factors, family history, medications, and glucose history.

To the best of our knowledge, this was the first study to determine a positive correlation between TG/HDL-C ratio variability and new-onset diabetes in a large cohort. These findings were confirmed in sensitivity and subgroup analyses, suggesting that this relation was fairly universal.

Further epidemiological experimental research should be performed to confirm this finding and to gain a fuller understanding of the mechanisms linking visit-to-visit TG/HDL-C ratio variability and diabetes.

 – Researchers

For complete details of the study, click here.


Source: J Diabetes Investig 2021;doi:10.1111/jdi.13536

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