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Doxycycline Treatment Outperforms Azithromycin for Patients with Rectal Chlamydia, Study Finds

According to a study that patients with rectal chlamydia infection may feel better with a  weeklong course of doxycycline than with a single dose of azithromycin.

Photo: InStyleHealth

Research enrolled men who have sexual contact with men who caught rectal chlamydia trachomatis (CT) infection. Patients were randomized to treatment with azithromycin (with single 1-gram dosage) or doxycycline (with 100 mg twice a day for 7 days).

Patients underwent repeated collection of rectal swabs for nucleic acid amplification testing (NAAT) at baseline and weeks 2 and 4 after enrolment. Preliminary result was microbiologic cure (CT-negative NAAT) at 4 weeks.

There were 135 patients (76%) had a CT-positive NAAT at baseline and available follow-up NAAT result at the 4-week follow-up and were included in the complete case (CC) population. The other 33 patients (19%) were excluded, because the CT NAAT repeated at the baseline was already negative.

Patients who were treated with doxycycline attained the primary result of the microbiologic cure, whereas only about three-fourths of those who received the azithromycin did in the CC population (100% vs 74%).

The results obtained were similar in the ITT population, with doxycycline exhibiting superiority over azithromycin treatment (91% vs 71%) translating to microbiological cure among patients. For details of the study, click here.


Source: Clin Infect Dis 2021;doi:10.1093/cid/ciab153

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