A recent study has found the risk of sustaining hip fractures is increased in patients with type 2 diabetes (TD2), specifically in women and in those with suboptimal cardiometabolic-renal health.
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Experts performed a prospective analysis of 22,325 T2D
patients average age of greater than 40 years; 52.4% of them were male who are
enrolled from the Hong Kong Diabetes Register between 1994 and 2015. Over an
average follow-up period of 8.7 years, 603 hip fracture admissions were
reported, with 189 in men and 414 in women.
The overall crude hip fracture incidence rate was at 315.1
per 100,000 person years. Patients who sustained hip fractures were
significantly older, more likely to be women, had longer diabetes period, and
had generally worse micro and macrovascular and cardiometabolic health in them.
Subsequently excluding 308 patients with past major
osteoporotic fractures (MOF), Cox regression analysis was conducted on 22,017
patients, of whom 588 and 399 suffered hip fractures or other MOFs,
respectively; the remaining participants did not develop or had MOF.
Comparing participants who did not suffer any fracture,
the following factors significantly increased the risk of hip fractures: female
gender, age, body mass index (BMI), albuminuria, and low-density lipoprotein
cholesterol (LDL).
Results of the study were consistent even when
participants who developed non-hip fracture MOFs were included to the healthy
controls as comparators.
For complete details of the study, click here.
Source: J Diabetes Investig 2021;doi:10.1111/jdi.13529