Diabetes in Women Heightens Risk of Hip Fracture, Study Finds

A recent study has found the risk of sustaining hip fractures is increased in patients with type 2 diabetes (TD2), specifically in women and in those with suboptimal cardiometabolic-renal health.


Photo: Diabetes in Women | InStyleHealth


Experts performed a prospective analysis of 22,325 T2D patients average age of greater than 40 years; 52.4% of them were male who are enrolled from the Hong Kong Diabetes Register between 1994 and 2015. Over an average follow-up period of 8.7 years, 603 hip fracture admissions were reported, with 189 in men and 414 in women.


The overall crude hip fracture incidence rate was at 315.1 per 100,000 person years. Patients who sustained hip fractures were significantly older, more likely to be women, had longer diabetes period, and had generally worse micro and macrovascular and cardiometabolic health in them.


Subsequently excluding 308 patients with past major osteoporotic fractures (MOF), Cox regression analysis was conducted on 22,017 patients, of whom 588 and 399 suffered hip fractures or other MOFs, respectively; the remaining participants did not develop or had MOF.


Comparing participants who did not suffer any fracture, the following factors significantly increased the risk of hip fractures: female gender, age, body mass index (BMI), albuminuria, and low-density lipoprotein cholesterol (LDL).


Results of the study were consistent even when participants who developed non-hip fracture MOFs were included to the healthy controls as comparators.

For complete details of the study, click here.


 

Source: J Diabetes Investig 2021;doi:10.1111/jdi.13529

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