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Creatine Supplementation Improves Muscle Metabolism in Children with Myositis, Study Reveals

A study reveals that supplementation with creatine in children with juvenile dermatomyositis (JDM) is not only feasible but safe and well-tolerated as well, potentially resulting in improvements in muscle metabolism.

Photo: Creatine Powder | InStyleHealth

What is Juvenile Dermatomyositis?

Juvenile dermatomyositis or JDM is a rare autoimmune disorder in which the immune system attacks blood vessels throughout the body called vasculopathy, causing muscle inflammation known as myositis.

Researchers performed a 6-month, double-blind, randomized, multiple-baseline study, in which patients were assigned to either creatine supplementation or placebo. They evaluated feasibility using attended study visits, completed study procedures, and adherence.

Utilizing the standardized exercise tests to examine muscle function, aerobic capacity, and muscle strength; a 31-Phosphorous Magnetic Resonance Spectroscopy protocol to evaluate muscle metabolism; and questionnaires to measure fatigue, physical activity, and quality of life (QoL).

The researchers estimated statistical significance using a randomization (permutation) test and calculated changes in result measures taken at baseline and end of study utilizing paired t—tests.

Average adherence to creatine supplementation stood at 88.5%, while the proportion of participants with > 89%-adherence was 76.9%. No study visits were missed.

Moreover, there as no statistically significant changes were detected in muscle function, strength, aerobic capacity, disease activity, fatigue, physical activity, or QoL while participants were receiving creatine compared with placebo.

At the conclusion of the study, statistically significant adaptations were noticed in muscle metabolism (e.g., decrease in change in muscle pH following exercise and decrease in phosphate/phosphocreatine ratio) relative to baseline. Significant adverse effects were not recorded nor detected.

For further details of the study, you may click here.


Source: J Rheumatol 2021;48:434-441

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