COVID-19 Mortality Lower Among Statin Users, Study Reveals

A recent study has revealed that patients already on statin medication upon COVID-19 infection seem to have lower mortality rates.


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There are 2,626 COVID-19 patients admitted between February 1st and May 12th 2020 were retrospectively assessed by the researchers. The core study result was in-hospital mortality occurring within 30 days of admission, while mechanical ventilation during the same time span was a secondary result. The impact of antecedent statin usage on the results was estimated.


What are statins?

Statins are medicinal drugs that can lower your cholesterol level. Statins work by blocking a substance your body needs to produce cholesterol. Lowering cholesterol is not the only benefit associated with statins. These medications have also been correlated to a lower risk of heart disease and stroke.


A total of 951 or 36.2% of the participants had antecedent statin use upon admission. The patients are relatively older, however, no other differences in baseline demographics were recorded. Regarding comorbidities – hypertension, diabetes, coronary artery disease, chronic kidney disease, and heart failure were all prevalent among statin users.


A one-to-one propensity matching resulted a final group size of 1,296 patients of whom 648 were on statins. Previously detected characteristic differences were mitigated in this group.


There were 96 statin users eventually died, which is lower compared to 172 mortality in the non-user group. The following mortality rates were also different (14.8% vs 26.5%), conforming to a significantly suppressed odds of mortality correlated with antecedent statin usage.


However, multivariable adjustment did not significantly change the outcome, such that antecedent statin usage remained statistically protective against in-hospital mortality within 30 days of admission among COVID-19 patients.


Statin usage was also correlated with a reduction in the possibility of the secondary outcome, albeit only attaining borderline significance according to researchers. For complete details of the study, click here.

 


Source: Nat Commun 2021;12:1325

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