Health Updates

On-demand Use of Dapoxetine Has Improved In Treating Patients With Premature Ejaculation

A recent China study reports that the ‘On-demand’ use of dapoxetine has helped improve ejaculation and s**ual satisfaction without significant safety issues in men with premature ejaculation (PE).

Photo: Premature Ejaculation (PE) Issue | InStyleHealth

The said study conducted a real-world phase IV study on 1,244 PE patients who were given 30 mg dapoxetine. If the subjects reported no improvement, the dosage was increased to 60 mg, and the medication was administered for 4 more weeks. A self-reported PE profile questionnaire was processed to assess the condition of severity and treatment safety and efficacy of the medication.

Although no deaths or fatalities occurred during the study period; however, a fifth of the patients or 18.6 percent reported experiencing treatment-emergent adverse events or TEAEs, most of which are considered mild. 

Dizziness, nausea, and headache were the most common side effects, both in patients who stayed on the 30 mg dosage and in those who needed an increased dosage to 60 mg. There were no episodes of syncope or fainting were reported. Serious adverse events (AEs) included cholecystitis and salivary gland cysts, none of which were deemed dapoxetine related.

After a month of observation, 1,052 patients receiving only the 30 mg dosage of dapoxetine had their data available for efficacy analysis. Among the 928 men in this subgroup, intervention was considered successful, as it yielded an effectiveness rate of 88.2 percent. 

For the 192 male patients, whose doses were increased to 60 mg, the medication was effective in 107 men, resulting to 55.7 percent of efficacy. Overall, 83.2 percent of the participants responded to the treatment regardless of the dose administered.

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